Nature Communications (Sep 2020)

Enteroendocrine cells couple nutrient sensing to nutrient absorption by regulating ion transport

  • Heather A. McCauley,
  • Andrea L. Matthis,
  • Jacob R. Enriquez,
  • Jonah T. Nichol,
  • J. Guillermo Sanchez,
  • William J. Stone,
  • Nambirajan Sundaram,
  • Michael A. Helmrath,
  • Marshall H. Montrose,
  • Eitaro Aihara,
  • James M. Wells

DOI
https://doi.org/10.1038/s41467-020-18536-z
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 10

Abstract

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Enteroendocrine cells (EECs) are specialized gastrointestinal cells that have a role in nutrient sensing and hormone secretion. Here the authors show that peptide YY from EECs regulates nutrient absorption in intestinal organoids.