Nature Communications (Sep 2021)
SARS-CoV-2 mucosal antibody development and persistence and their relation to viral load and COVID-19 symptoms
- Janeri Fröberg,
- Joshua Gillard,
- Ria Philipsen,
- Kjerstin Lanke,
- Joyce Rust,
- Diana van Tuijl,
- Karina Teelen,
- Teun Bousema,
- Elles Simonetti,
- Christa E. van der Gaast-de Jongh,
- Mariska Bos,
- Frank J. van Kuppeveld,
- Berend-Jan Bosch,
- Marrigje Nabuurs-Franssen,
- Nannet van der Geest-Blankert,
- Charlotte van Daal,
- Martijn A. Huynen,
- Marien I. de Jonge,
- Dimitri A. Diavatopoulos
Affiliations
- Janeri Fröberg
- Radboud University Medical Centre, Radboud Institute for Molecular Life Sciences, Laboratory of Medical Immunology, Section Paediatric Infectious Diseases
- Joshua Gillard
- Radboud University Medical Centre, Radboud Institute for Molecular Life Sciences, Laboratory of Medical Immunology, Section Paediatric Infectious Diseases
- Ria Philipsen
- Radboud University Medical Centre, Radboud Institute for Molecular Life Sciences, Laboratory of Medical Immunology, Section Paediatric Infectious Diseases
- Kjerstin Lanke
- Radboud Center for Infectious Diseases, Radboudumc
- Joyce Rust
- Radboud University Medical Centre, Radboud Institute for Molecular Life Sciences, Laboratory of Medical Immunology, Section Paediatric Infectious Diseases
- Diana van Tuijl
- Radboud University Medical Centre, Radboud Institute for Molecular Life Sciences, Laboratory of Medical Immunology, Section Paediatric Infectious Diseases
- Karina Teelen
- Radboud Center for Infectious Diseases, Radboudumc
- Teun Bousema
- Radboud Center for Infectious Diseases, Radboudumc
- Elles Simonetti
- Radboud University Medical Centre, Radboud Institute for Molecular Life Sciences, Laboratory of Medical Immunology, Section Paediatric Infectious Diseases
- Christa E. van der Gaast-de Jongh
- Radboud University Medical Centre, Radboud Institute for Molecular Life Sciences, Laboratory of Medical Immunology, Section Paediatric Infectious Diseases
- Mariska Bos
- Radboud University Medical Centre, Radboud Institute for Molecular Life Sciences, Laboratory of Medical Immunology, Section Paediatric Infectious Diseases
- Frank J. van Kuppeveld
- Utrecht University, Faculty of Veterinary Medicine, Department of Biomolecular Health Sciences, Division Infectious Diseases and Immunology
- Berend-Jan Bosch
- Utrecht University, Faculty of Veterinary Medicine, Department of Biomolecular Health Sciences, Division Infectious Diseases and Immunology
- Marrigje Nabuurs-Franssen
- Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital
- Nannet van der Geest-Blankert
- Department of Occupational Health, Radboud University Medical Centre
- Charlotte van Daal
- Department of Occupational Health, Radboud University Medical Centre
- Martijn A. Huynen
- Centre for molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre Nijmegen
- Marien I. de Jonge
- Radboud University Medical Centre, Radboud Institute for Molecular Life Sciences, Laboratory of Medical Immunology, Section Paediatric Infectious Diseases
- Dimitri A. Diavatopoulos
- Radboud University Medical Centre, Radboud Institute for Molecular Life Sciences, Laboratory of Medical Immunology, Section Paediatric Infectious Diseases
- DOI
- https://doi.org/10.1038/s41467-021-25949-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
There has been limited research on the role of the mucosal immune response to SARS-CoV-2 infection. Here, the authors perform a prospective observational household study and find that mucosal antibody responses are associated with decreased viral load and faster resolution of systemic symptoms.
