Phonon lasing enhanced mass sensor with zeptogram resolution under ambient conditions

Fei Pan; Kaiyu Cui; Yidong Huang; Ziming Chen; Ning Wu; Guoren Bai; Zhilei Huang; Xue Feng; Fang Liu; Wei Zhang

Chip (Sep 2023)

Phonon lasing enhanced mass sensor with zeptogram resolution under ambient conditions

Fei Pan,
Kaiyu Cui,
Yidong Huang,
Ziming Chen,
Ning Wu,
Guoren Bai,
Zhilei Huang,
Xue Feng,
Fang Liu,
Wei Zhang

Affiliations

Fei Pan: Department of Electronic Engineering, Tsinghua University, Beijing 100084, China; Beijing National Research Center for Information Science and Technology (BNRist), Beijing 100084, China
Kaiyu Cui: Corresponding authors at: Department of Electronic Engineering, Tsinghua University, Beijing 100084, P. R. China; Beijing National Research Center for Information Science and Technology (BNRist), Beijing 100084, China; Department of Electronic Engineering, Tsinghua University, Beijing 100084, China; Beijing National Research Center for Information Science and Technology (BNRist), Beijing 100084, China
Yidong Huang: Corresponding authors at: Department of Electronic Engineering, Tsinghua University, Beijing 100084, P. R. China; Beijing National Research Center for Information Science and Technology (BNRist), Beijing 100084, China; Department of Electronic Engineering, Tsinghua University, Beijing 100084, China; Beijing National Research Center for Information Science and Technology (BNRist), Beijing 100084, China
Ziming Chen: Department of Electronic Engineering, Tsinghua University, Beijing 100084, China; Beijing National Research Center for Information Science and Technology (BNRist), Beijing 100084, China
Ning Wu: Department of Electronic Engineering, Tsinghua University, Beijing 100084, China; Beijing National Research Center for Information Science and Technology (BNRist), Beijing 100084, China
Guoren Bai: Department of Electronic Engineering, Tsinghua University, Beijing 100084, China; Beijing National Research Center for Information Science and Technology (BNRist), Beijing 100084, China
Zhilei Huang: Department of Electronic Engineering, Tsinghua University, Beijing 100084, China; Beijing National Research Center for Information Science and Technology (BNRist), Beijing 100084, China
Xue Feng: Department of Electronic Engineering, Tsinghua University, Beijing 100084, China; Beijing National Research Center for Information Science and Technology (BNRist), Beijing 100084, China
Fang Liu: Department of Electronic Engineering, Tsinghua University, Beijing 100084, China; Beijing National Research Center for Information Science and Technology (BNRist), Beijing 100084, China
Wei Zhang: Department of Electronic Engineering, Tsinghua University, Beijing 100084, China; Beijing National Research Center for Information Science and Technology (BNRist), Beijing 100084, China

Journal volume & issue: Vol. 2, no. 3
p. 100050

Abstract

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ABSTRACT: High-sensitivity mass sensors under ambient conditions are essential in various fields such as biological research, gas sensing and environmental monitoring. In the current work, a phonon lasing enhanced mass sensor was proposed based on an optomechanical crystal cavity under ambient conditions. The phonon lasing was harnessed to achieve ultra-high resolution since it resulted in an extremely narrow mechanical linewidth (less than 10 kHz). Masses with different weights were deposited on the cavity, it is predicted that the maximum resolution for mass sensing can be 65 ± 19 zg, which approaches the mass order of a protein and an oligonucleotide. This implies the potential application of the proposed method in the biomedical fields such as oligonucleotide drug delivery area and the Human Proteome Project.

Published in Chip

ISSN: 2709-4723 (Print); 2772-2724 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Technology: Technology (General): Industrial engineering. Management engineering: Information technology
Website: https://www.sciencedirect.com/journal/chip

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