COMPARAÇÃO ENTRE MODOS DE ADMINISTRAÇÃO DE FITOTERÁPICOS A BASE DE MELISSA OFFICINALIS – UMA DISCUSSÃO FARMACOCINÉTICA

Abstract

The Melissa officinalisL. (Lamiaceae) presents high levels of phenolic compounds that have a serie of biological effects, as anti-inflammatory that inhibits the activity of cyclooxygenase and inhibition of Cytochromes P450. Due to his biological effects, it is in evidence in diverse studies. They are present in vegetables and in diverse forms in our food, like tea and herbal capsules. The objective this study was to compare the difference in availability of active molecules from medicinal plants in two different forms of use, capsules and tea. After simulation in vitro of gastric digestion, the total phenolic compounds were determined employing a spectrophotometric method Folin-Ciocalteau. We obtained higher values of total phenols in the digestion of capsules than in Melissa officinalis. It indicates that probably the capsules presents more availability of active ingredients that infusions. It is worth mentioning the need for further studies to compare the total phenol content of Melissa officinalisinfusions, as well as the use of other plants to verify the best use of medicinal plants.

Keywords

• Total phenols
• Folin-ciocalteau
• Melissa officinalis