Nature Communications (Oct 2022)

Polerovirus N-terminal readthrough domain structures reveal molecular strategies for mitigating virus transmission by aphids

  • Carl J. Schiltz,
  • Jennifer R. Wilson,
  • Christopher J. Hosford,
  • Myfanwy C. Adams,
  • Stephanie E. Preising,
  • Stacy L. DeBlasio,
  • Hannah J. MacLeod,
  • Joyce Van Eck,
  • Michelle L. Heck,
  • Joshua S. Chappie

DOI
https://doi.org/10.1038/s41467-022-33979-2
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 13

Abstract

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The authors present structures of plant polerovirus NRTD proteins that protrude from the viral capsid and show that the purified NRTD can inhibit insect transmission and act as a bioinsecticide, providing a blueprint for control of related viruses.