A Long-Lasting PARP1-Activation Mediates Signal-Induced Gene Expression

Abstract

This overview presents recent evidence for a long-lasting PARP1 activation by a variety of signal transduction mechanisms, mediating signal-induced gene expression and chromatin remodeling. This mode of PARP1 activation has been reported in a variety of cell types, under physiological conditions. In this mechanism, PARP1 is not transiently activated by binding to DNA breaks. Moreover, damaged DNA interfered with this long-lasting PARP1 activation.

Keywords

• PARP1 activation
• H1 polyADP-ribosylation
• signal transduction pathways
• immediate early gene expression
• histone acetylation
• DNA methylation