MicroRNA-146a limits tumorigenic inflammation in colorectal cancer

Lucien P. Garo; Amrendra K. Ajay; Mai Fujiwara; Galina Gabriely; Radhika Raheja; Chantal Kuhn; Brendan Kenyon; Nathaniel Skillin; Ryoko Kadowaki-Saga; Shrishti Saxena; Gopal Murugaiyan

doi:10.1038/s41467-021-22641-y

Nature Communications (Apr 2021)

MicroRNA-146a limits tumorigenic inflammation in colorectal cancer

Lucien P. Garo,
Amrendra K. Ajay,
Mai Fujiwara,
Galina Gabriely,
Radhika Raheja,
Chantal Kuhn,
Brendan Kenyon,
Nathaniel Skillin,
Ryoko Kadowaki-Saga,
Shrishti Saxena,
Gopal Murugaiyan

Affiliations

Lucien P. Garo: Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School
Amrendra K. Ajay: Renal Division, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
Mai Fujiwara: Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School
Galina Gabriely: Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School
Radhika Raheja: Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School
Chantal Kuhn: Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School
Brendan Kenyon: Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School
Nathaniel Skillin: Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School
Ryoko Kadowaki-Saga: Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School
Shrishti Saxena: Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School
Gopal Murugaiyan: Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School

DOI: https://doi.org/10.1038/s41467-021-22641-y
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

Read online

Activation of interleukin-17 (IL-17) receptor signaling within intestinal epithelial cells (IECs) promotes colorectal cancer development. Here, the authors show that miR-146a limits inflammation-induced colorectal carcinogenesis by inhibiting both IL-17 induction from myeloid cells and inhibiting IL-17R signaling within IECs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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