Fractional exhaled nitric oxide distribution and its relevant factors in the general adult population and its healthy subpopulation

Mitsuhiro Yamada, MD, PhD; Masato Takase, MPH; Kumi Nakaya, PhD; Tomohiro Nakamura, PhD; Mana Kogure, PhD; Naoki Nakaya, PhD; Naoya Fujino, MD, PhD; Tsutomu Tamada, MD, PhD; Chikashi Iwasaki, MD; Manami Suzuki, MD; Shuichiro Matsumoto, MD; Nobuo Fuse, MD, PhD; Akira Uruno, MD, PhD; Kazuki Kumada, PhD; Soichi Ogishima, PhD; Shinichi Kuriyama, MD, PhD; Masakazu Ichinose, MD, PhD; Hisatoshi Sugiura, MD, PhD; Atsushi Hozawa, MD, PhD

Journal of Allergy and Clinical Immunology: Global (Aug 2024)

Fractional exhaled nitric oxide distribution and its relevant factors in the general adult population and its healthy subpopulation

Mitsuhiro Yamada, MD, PhD,
Masato Takase, MPH,
Kumi Nakaya, PhD,
Tomohiro Nakamura, PhD,
Mana Kogure, PhD,
Naoki Nakaya, PhD,
Naoya Fujino, MD, PhD,
Tsutomu Tamada, MD, PhD,
Chikashi Iwasaki, MD,
Manami Suzuki, MD,
Shuichiro Matsumoto, MD,
Nobuo Fuse, MD, PhD,
Akira Uruno, MD, PhD,
Kazuki Kumada, PhD,
Soichi Ogishima, PhD,
Shinichi Kuriyama, MD, PhD,
Masakazu Ichinose, MD, PhD,
Hisatoshi Sugiura, MD, PhD,
Atsushi Hozawa, MD, PhD

Affiliations

Mitsuhiro Yamada, MD, PhD: Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan; Corresponding authors: Mitsuhiro Yamada, MD, PhD, Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 9808574, Japan.
Masato Takase, MPH: Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
Kumi Nakaya, PhD: Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
Tomohiro Nakamura, PhD: Kyoto Women’s University, Kyoto, Japan
Mana Kogure, PhD: Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
Naoki Nakaya, PhD: Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
Naoya Fujino, MD, PhD: Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
Tsutomu Tamada, MD, PhD: Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
Chikashi Iwasaki, MD: Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
Manami Suzuki, MD: Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
Shuichiro Matsumoto, MD: Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
Nobuo Fuse, MD, PhD: Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
Akira Uruno, MD, PhD: Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
Kazuki Kumada, PhD: Department of Biobank, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
Soichi Ogishima, PhD: Department of Health Record Informatics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
Shinichi Kuriyama, MD, PhD: Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
Masakazu Ichinose, MD, PhD: Osaki Citizen Hospital Academic Center, Osaki, Japan
Hisatoshi Sugiura, MD, PhD: Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
Atsushi Hozawa, MD, PhD: Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Atsushi Hozawa, MD, PhD, Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 9808573, Japan.

Journal volume & issue: Vol. 3, no. 3
p. 100253

Abstract

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Background: Measurement of fractional exhaled nitric oxide (Feno) has been used in the diagnosis and management of asthma. Understanding the distribution of Feno in a larger resident population and its “healthy” subpopulation would contribute to the interpretation of Feno in clinical practice. Objective: This study aimed to investigate the distribution and its associated factors in the adult population and its healthy subpopulations. Methods: We conducted a cross-sectional study of 8,638 men and 17,288 women aged 20 years or older living in Miyagi prefecture, Japan. We investigated the distribution of Feno and its associated factors in all subjects, a subpopulation with no history of upper and lower airway diseases (healthy subpopulation 1), and a subpopulation with no history of upper and lower airway diseases, normal lung function, and no positivity for other biomarkers of type 2 inflammation (healthy subpopulation 2). Results: The distribution of Feno in healthy subpopulations, especially in healthy subpopulation 2 (median [interquartile range], 17 [12-23] with 95th percentile of 36 ppb) was lower than in all subjects (19 [13-26] ppb with 95th percentile of 47 ppb). In healthy subpopulation 1, 10.3% had elevated Feno (≥35 ppb), and elevated Feno was positively associated with factors including obstructive ventilatory defect, blood eosinophilia, house dust mite–specific IgE positivity, and history of hypertension. Male sex was associated with elevated Feno in all subjects and healthy subpopulations. Conclusion: The distribution of Feno in the healthy subpopulation supports the validity of the criteria (≥35 ppb) currently used in Japan for the diagnosis of asthma.

Published in Journal of Allergy and Clinical Immunology: Global

ISSN: 2772-8293 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: https://www.sciencedirect.com/journal/journal-of-allergy-and-clinical-immunology-global

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