Pd(II)-catalysed meta-C–H functionalizations of benzoic acid derivatives

Shangda Li; Lei Cai; Huafang Ji; Long Yang; Gang Li

doi:10.1038/ncomms10443

Nature Communications (Jan 2016)

Pd(II)-catalysed meta-C–H functionalizations of benzoic acid derivatives

Shangda Li,
Lei Cai,
Huafang Ji,
Long Yang,
Gang Li

Affiliations

Shangda Li: State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences
Lei Cai: State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences
Huafang Ji: State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences
Long Yang: State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences
Gang Li: State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/ncomms10443
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 8

Abstract

Read online

While directed ortho-metalation is a well-established protocol, meta-functionalisation of aromatic groups is more challenging. Here, the authors report a directed meta-C-H functionalisation of benzoic acid derivatives, using a nitrile-based sulfonamide directing group.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal