Checkpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice

Wenwen Yue; Liang Chen; Luodan Yu; Bangguo Zhou; Haohao Yin; Weiwei Ren; Chang Liu; Lehang Guo; Yifeng Zhang; Liping Sun; Kun Zhang; Huixiong Xu; Yu Chen

doi:10.1038/s41467-019-09760-3

Nature Communications (May 2019)

Checkpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice

Wenwen Yue,
Liang Chen,
Luodan Yu,
Bangguo Zhou,
Haohao Yin,
Weiwei Ren,
Chang Liu,
Lehang Guo,
Yifeng Zhang,
Liping Sun,
Kun Zhang,
Huixiong Xu,
Yu Chen

Affiliations

Wenwen Yue: Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine
Liang Chen: Department of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine
Luodan Yu: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences
Bangguo Zhou: Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine
Haohao Yin: Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine
Weiwei Ren: Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine
Chang Liu: Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine
Lehang Guo: Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine
Yifeng Zhang: Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine
Liping Sun: Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine
Kun Zhang: Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine
Huixiong Xu: Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine
Yu Chen: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-019-09760-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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Immunotherapy for the treatment of cancer can be complicated by side effects and poor efficacy. Here, the authors use a nanoparticle-based approach in combination with a TLR7 agonist and sonodynamic therapy, and find that when used together with anti-PD-L1, tumour formation and metastases are impacted.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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