Communications Biology (Feb 2022)

Pitavastatin activates mitophagy to protect EPC proliferation through a calcium-dependent CAMK1-PINK1 pathway in atherosclerotic mice

  • Jie Yang,
  • Mengjia Sun,
  • Ran Cheng,
  • Hu Tan,
  • Chuan Liu,
  • Renzheng Chen,
  • Jihang Zhang,
  • Yuanqi Yang,
  • Xubin Gao,
  • Lan Huang

DOI
https://doi.org/10.1038/s42003-022-03081-w
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 17

Abstract

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Endothelial progenitor cell (EPCs) proliferation decreased, accompanied by mitochondrial dysfunction and mitophagy impairment via the PINK1-PARK2 pathway in atherosclerosis. Statins induce mitophagy to protect EPCs by mitochondrial calcium release and CAMK1-mediated PINK1 phosphorylation.