Nature Communications (Apr 2020)
Glycogen metabolism regulates macrophage-mediated acute inflammatory responses
- Jingwei Ma,
- Keke Wei,
- Junwei Liu,
- Ke Tang,
- Huafeng Zhang,
- Liyan Zhu,
- Jie Chen,
- Fei Li,
- Pingwei Xu,
- Jie Chen,
- Jincheng Liu,
- Haiqing Fang,
- Liang Tang,
- Dianheng Wang,
- Liping Zeng,
- Weiwei Sun,
- Jing Xie,
- Yuying Liu,
- Bo Huang
Affiliations
- Jingwei Ma
- Department of Immunology, Tongji Medical College, Huazhong University of Science & Technology
- Keke Wei
- Department of Biochemistry & Molecular Biology, Tongji Medical College, Huazhong University of Science & Technology
- Junwei Liu
- Cardiovascular Surgery, Union Hospital, Huazhong University of Science & Technology
- Ke Tang
- Department of Biochemistry & Molecular Biology, Tongji Medical College, Huazhong University of Science & Technology
- Huafeng Zhang
- Department of Biochemistry & Molecular Biology, Tongji Medical College, Huazhong University of Science & Technology
- Liyan Zhu
- Department of Biochemistry & Molecular Biology, Tongji Medical College, Huazhong University of Science & Technology
- Jie Chen
- Cardiovascular Surgery, Union Hospital, Huazhong University of Science & Technology
- Fei Li
- Department of Immunology, Tongji Medical College, Huazhong University of Science & Technology
- Pingwei Xu
- Department of Biochemistry & Molecular Biology, Tongji Medical College, Huazhong University of Science & Technology
- Jie Chen
- Department of Biochemistry & Molecular Biology, Tongji Medical College, Huazhong University of Science & Technology
- Jincheng Liu
- Department of Biochemistry & Molecular Biology, Tongji Medical College, Huazhong University of Science & Technology
- Haiqing Fang
- Department of Biochemistry & Molecular Biology, Tongji Medical College, Huazhong University of Science & Technology
- Liang Tang
- Department of Immunology, Tongji Medical College, Huazhong University of Science & Technology
- Dianheng Wang
- Department of Biochemistry & Molecular Biology, Tongji Medical College, Huazhong University of Science & Technology
- Liping Zeng
- Department of Biochemistry & Molecular Biology, Tongji Medical College, Huazhong University of Science & Technology
- Weiwei Sun
- Department of Biochemistry & Molecular Biology, Tongji Medical College, Huazhong University of Science & Technology
- Jing Xie
- Department of Immunology & National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College
- Yuying Liu
- Department of Immunology & National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College
- Bo Huang
- Department of Immunology, Tongji Medical College, Huazhong University of Science & Technology
- DOI
- https://doi.org/10.1038/s41467-020-15636-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
Glycogen can be metabolized via glycogenolysis and the pentose phosphate pathway as well as into the production of UDP glucose, which when secreted can bind the P2Y14 receptor. Here the authors show how these glycogen metabolism pathways contribute to proinflammatory macrophage activation and susceptibility to sepsis.
