Nature Communications (Mar 2020)
Cancer associated fibroblast FAK regulates malignant cell metabolism
- Fevzi Demircioglu,
- Jun Wang,
- Juliana Candido,
- Ana S. H. Costa,
- Pedro Casado,
- Beatriz de Luxan Delgado,
- Louise E. Reynolds,
- Jesus Gomez-Escudero,
- Emma Newport,
- Vinothini Rajeeve,
- Ann-Marie Baker,
- Marina Roy-Luzarraga,
- Trevor A. Graham,
- Julie Foster,
- Yu Wang,
- James J. Campbell,
- Rajinder Singh,
- Penglie Zhang,
- Thomas J. Schall,
- Frances R. Balkwill,
- Jane Sosabowski,
- Pedro R. Cutillas,
- Christian Frezza,
- Patricia Sancho,
- Kairbaan Hodivala-Dilke
Affiliations
- Fevzi Demircioglu
- Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre
- Jun Wang
- Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre
- Juliana Candido
- Centre for Cancer and Inflammation, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre
- Ana S. H. Costa
- MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre
- Pedro Casado
- Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre
- Beatriz de Luxan Delgado
- Centre for Stem Cells in Cancer and Ageing, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre
- Louise E. Reynolds
- Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre
- Jesus Gomez-Escudero
- Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre
- Emma Newport
- Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre
- Vinothini Rajeeve
- Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre
- Ann-Marie Baker
- Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre
- Marina Roy-Luzarraga
- Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre
- Trevor A. Graham
- Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre
- Julie Foster
- Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre
- Yu Wang
- ChemoCentryx Inc.
- James J. Campbell
- ChemoCentryx Inc.
- Rajinder Singh
- ChemoCentryx Inc.
- Penglie Zhang
- ChemoCentryx Inc.
- Thomas J. Schall
- ChemoCentryx Inc.
- Frances R. Balkwill
- Centre for Cancer and Inflammation, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre
- Jane Sosabowski
- Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre
- Pedro R. Cutillas
- Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre
- Christian Frezza
- MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre
- Patricia Sancho
- Centre for Stem Cells in Cancer and Ageing, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre
- Kairbaan Hodivala-Dilke
- Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre
- DOI
- https://doi.org/10.1038/s41467-020-15104-3
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
Cancer associated fibroblasts (CAFs) have been suggested to regulate cancer cell metabolism, but the mechanisms are not completely elucidated. Here, the authors show that low FAK expression in stromal cells correlates with poor prognosis in breast and pancreatic cancer patients and that FAK-silencing in CAFs promotes tumourigenesis by the paracrine regulation of cancer cell metabolism.
