Nature Communications (Feb 2020)

Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection

  • Yao Wei,
  • Ming Lu,
  • Meng Mei,
  • Haoran Wang,
  • Zhitao Han,
  • Miaomiao Chen,
  • Hang Yao,
  • Nanshan Song,
  • Xiao Ding,
  • Jianhua Ding,
  • Ming Xiao,
  • Gang Hu

DOI
https://doi.org/10.1038/s41467-020-14788-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

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Dopamine agonists increase brain glutathione levels. Here the authors identify noncanonical signalling by Nrf2 as a potential mechanism for the neuroprotective effects of dopamine D2 receptor activation.