Revista de la Facultad de Medicina Humana (Mar 2021)

Characterization of the V4 and T1 polymorphism of the ADAM33 gene and its association with the development of asthma

  • Clarisa Carolina Arrascue Vega,
  • Rossana Menendez Nuñez,
  • Walter Gutierrez Celestino-Segura,
  • Luis Miguel Serquén López,
  • Alain Eduard Monsalve Mera

DOI
https://doi.org/10.25176/RFMH.v21i2.3450
Journal volume & issue
Vol. 21, no. 2
pp. 261 – 268

Abstract

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Objective: To determine the association between the presence of V4 polymorphisms of the ADAM33 gene and asthma disease and to describe the frequency of T1 polymorphism in patients from a hospital in the Lambayeque region. Materials and methods: Design of cases and controls. Location: Hospital Almanzor Aguinaga Asenjo - EsSalud, level of complexity III-1. Population: patients between 5-17 years old attended by an outpatient clinic. The cases were patients diagnosed according to the Global Initiative for Asthma (GINA) 2016 guidelines. Controls were patients without a diagnosis of any chronic lung disease or a family history of asthma. Results: In most cases, both cases and controls did not present the V4 polymorphism, I feel positive only in 46% of cases and 31% of controls. When the association between the V4 polymorphism and the presence of asthma was evaluated, the OR was 1.93 (95% CI: 0.62 - 6.00), with a non-significant value (p = 0.196) for the Xi test --Pearson square. However, the T1 polymorphism was present in 87% of cases; and the proportion of Tumbesinos with the mutation was much lower than that of other regions. Conclusions: No association was found between the V4 polymorphism and the presence of asthma in patients from a Lambayeque hospital. The T1 polymorphism occurs quite frequently in asthmatic patients at Hospital Almanzor Aguinaga Asenjo - ESSalud.

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