Nature Communications (Nov 2019)
Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity
- Mercedes Dávalos-Salas,
- Magdalene K. Montgomery,
- Camilla M. Reehorst,
- Rebecca Nightingale,
- Irvin Ng,
- Holly Anderton,
- Sheren Al-Obaidi,
- Analia Lesmana,
- Cameron M. Scott,
- Paul Ioannidis,
- Hina Kalra,
- Shivakumar Keerthikumar,
- Lars Tögel,
- Angela Rigopoulos,
- Sylvia J. Gong,
- David S. Williams,
- Prusoth Yoganantharaja,
- Kim Bell-Anderson,
- Suresh Mathivanan,
- Yann Gibert,
- Scott Hiebert,
- Andrew M. Scott,
- Matthew J. Watt,
- John M. Mariadason
Affiliations
- Mercedes Dávalos-Salas
- Olivia Newton John Cancer Research Institute
- Magdalene K. Montgomery
- Department of Physiology, Faculty of Medicine Dentistry and Health Sciences, University of Melbourne
- Camilla M. Reehorst
- Olivia Newton John Cancer Research Institute
- Rebecca Nightingale
- Olivia Newton John Cancer Research Institute
- Irvin Ng
- Olivia Newton John Cancer Research Institute
- Holly Anderton
- Olivia Newton John Cancer Research Institute
- Sheren Al-Obaidi
- Olivia Newton John Cancer Research Institute
- Analia Lesmana
- Olivia Newton John Cancer Research Institute
- Cameron M. Scott
- Olivia Newton John Cancer Research Institute
- Paul Ioannidis
- Olivia Newton John Cancer Research Institute
- Hina Kalra
- La Trobe Institute for Molecular Sciences, La Trobe University
- Shivakumar Keerthikumar
- La Trobe Institute for Molecular Sciences, La Trobe University
- Lars Tögel
- Olivia Newton John Cancer Research Institute
- Angela Rigopoulos
- Olivia Newton John Cancer Research Institute
- Sylvia J. Gong
- Olivia Newton John Cancer Research Institute
- David S. Williams
- Olivia Newton John Cancer Research Institute
- Prusoth Yoganantharaja
- Department of Medicine, Deakin University
- Kim Bell-Anderson
- Faculty of Science, Charles Perkins Centre, University of Sydney
- Suresh Mathivanan
- La Trobe Institute for Molecular Sciences, La Trobe University
- Yann Gibert
- Department of Medicine, Deakin University
- Scott Hiebert
- Vanderbilt University
- Andrew M. Scott
- Olivia Newton John Cancer Research Institute
- Matthew J. Watt
- Department of Physiology, Faculty of Medicine Dentistry and Health Sciences, University of Melbourne
- John M. Mariadason
- Olivia Newton John Cancer Research Institute
- DOI
- https://doi.org/10.1038/s41467-019-13180-8
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Histone deacetylase 3 (HDAC3) is a regulator of lipid homeostasis in several tissues, however, its role in intestinal lipid metabolism was not yet known. Here the authors study intestine specific HDAC3 knock out mice and report that these animals have increased fatty acid oxidation and undergo remodeling of the intestinal epithelial cell lipidome.
