International Journal of Cardiology: Heart & Vasculature (Jun 2021)
Cardiac computed tomography-derived extracellular volume fraction in late anthracycline-induced cardiotoxicity
- Koichi Egashira,
- Daisuke Sueta,
- Mai Tomiguchi,
- Masafumi Kidoh,
- Seitaro Oda,
- Hiroki Usuku,
- Kaori Hidaka,
- Lisa Goto-Yamaguchi,
- Aiko Sueta,
- Takashi Komorita,
- Masafumi Takae,
- Fumi Oike,
- Koichiro Fujisue,
- Eiichiro Yamamoto,
- Shinsuke Hanatani,
- Seiji Takashio,
- Yuichiro Arima,
- Satoshi Araki,
- Koichi Kaikita,
- Kenichi Matsushita,
- Yutaka Yamamoto,
- Toshinori Hirai,
- Kenichi Tsujita
Affiliations
- Koichi Egashira
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto, Japan; Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto, Japan
- Daisuke Sueta
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto, Japan; Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto, Japan; Corresponding author at: Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1, Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
- Mai Tomiguchi
- Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto, Japan
- Masafumi Kidoh
- Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto, Japan
- Seitaro Oda
- Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto, Japan
- Hiroki Usuku
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto, Japan; Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto, Japan; Department of Laboratory Medicine, Kumamoto University Hospital, Kumamoto, Japan
- Kaori Hidaka
- Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto, Japan
- Lisa Goto-Yamaguchi
- Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto, Japan
- Aiko Sueta
- Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto, Japan
- Takashi Komorita
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto, Japan; Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto, Japan
- Masafumi Takae
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto, Japan; Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto, Japan
- Fumi Oike
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto, Japan; Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto, Japan
- Koichiro Fujisue
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto, Japan; Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto, Japan
- Eiichiro Yamamoto
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto, Japan; Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto, Japan
- Shinsuke Hanatani
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto, Japan; Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto, Japan
- Seiji Takashio
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto, Japan; Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto, Japan
- Yuichiro Arima
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto, Japan; Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto, Japan
- Satoshi Araki
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto, Japan; Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto, Japan
- Koichi Kaikita
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto, Japan; Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto, Japan
- Kenichi Matsushita
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto, Japan; Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto, Japan; Division of Advanced Cardiovascular Therapeutics, Kumamoto University Hospital, Kumamoto, Japan
- Yutaka Yamamoto
- Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto, Japan
- Toshinori Hirai
- Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto, Japan
- Kenichi Tsujita
- Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto, Japan; Center for Metabolic Regulation of Healthy Aging, Graduate School of Medical Sciences, Kumamoto, Japan
- Journal volume & issue
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Vol. 34
p. 100797
Abstract
Cardiotoxicity in the late phase after anthracycline drugs administration remains to be defined. Of the 44 patients who received anthracycline treatment, 7 were found to have cancer therapeutics–related cardiac dysfunction (CTRCD). The global longitudinal strain determined by echocardiography and myocardial extracellular volume fraction (ECV) determined by cardiac computed tomography (CCT) of the CTRCD(+) group were significantly higher than those of the control group and CTRCD(-) group, whereas there were no significant differences between the control and CTRCD(-) groups. Our findings indicated that CCT may be a tool comparable to echocardiography, indicating the effective evaluation of CTRCD by CCT.
