Journal of Clinical and Diagnostic Research (Feb 2019)
Stromal Expression of CD10 in Colorectal Carcinoma and its Correlation with Lymph Node Metastasis and Other Prognostic Factors
Abstract
Introduction: Colorectal Carcinoma (CRC) is an important public health problem. The study has been one of the main preoccupation for researchers worldwide and continuous research is going on to find out methods for the early detection, control and drugs for targeted therapy to improve the survival rate. Aim: To study the expression of stromal CD10 (sCD10) in colorectal neoplasia and to find out if there is any significant difference between sCD10 expression in adenomas versus carcinoma and association of sCD10 expression with age, tumour grade, depth of invasion and nodal status in CRC. Materials and Methods: The present study was a prospective and retrospective observational study conducted in the Department of Pathology, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India, from August 2014 to July 2016. Expression of sCD10 in 71 cases including adenomas (12 cases) and adenocarcinomas (59 cases) were studied. Five tissues from proximal margin were included in the tissue microarray to study the pattern of sCD10 expression in the normal areas. Results: The age of patients ranged from 19-74 years with a male to female ratio of 1.62:1. The stromal expression of CD10 did not show any statistically significant association with any specific age group. In the present study, low grade adenoma was found to be negative for sCD10 but 50% (4/8) cases of high grade adenoma were positive for sCD10 expression. However, the values were not statistically significant. Of the total cases of CRC, 50.85% (30/59) cases showed no expression of sCD10 whereas 49.15% (29/59) cases were positive for sCD10 expression. Evaluation of sCD10 and lymph node status showed that 44.12% (15/34) node negative cases were sCD10 positive where as only 40.00% (10/25) node positive cases were sCD10 positive and these values were not statistically significant. Conclusion: In different grades of CRC sCD10 positivity did not show any statistically significant correlation, but the sCD10 expression was found to be increased with increased depth of tumour.
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