Cyclic di-AMP Oversight of Counter-Ion Osmolyte Pools Impacts Intrinsic Cefuroxime Resistance in Lactococcus lactis

Huong Thi Pham; Wen Shi; Yuwei Xiang; Su Yi Foo; Manuel R. Plan; Pascal Courtin; Marie-Pierre Chapot-Chartier; Eddy J. Smid; Zhao-Xun Liang; Esteban Marcellin; Mark S. Turner

doi:10.1128/mBio.00324-21

mBio (Apr 2021)

Cyclic di-AMP Oversight of Counter-Ion Osmolyte Pools Impacts Intrinsic Cefuroxime Resistance in Lactococcus lactis

Huong Thi Pham,
Wen Shi,
Yuwei Xiang,
Su Yi Foo,
Manuel R. Plan,
Pascal Courtin,
Marie-Pierre Chapot-Chartier,
Eddy J. Smid,
Zhao-Xun Liang,
Esteban Marcellin,
Mark S. Turner

Affiliations

Huong Thi Pham: School of Agriculture and Food Sciences, University of Queensland, Brisbane, Queensland, Australia
Wen Shi: School of Agriculture and Food Sciences, University of Queensland, Brisbane, Queensland, Australia
Yuwei Xiang: School of Agriculture and Food Sciences, University of Queensland, Brisbane, Queensland, Australia
Su Yi Foo: School of Agriculture and Food Sciences, University of Queensland, Brisbane, Queensland, Australia
Manuel R. Plan: Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Queensland, Australia
Pascal Courtin: Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas, France
Marie-Pierre Chapot-Chartier: ORCiD; Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas, France
Eddy J. Smid: Laboratory of Food Microbiology, Wageningen University and Research, Wageningen, The Netherlands
Zhao-Xun Liang: ORCiD; School of Biological Sciences, Nanyang Technological University, Singapore
Esteban Marcellin: Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Queensland, Australia
Mark S. Turner: ORCiD; School of Agriculture and Food Sciences, University of Queensland, Brisbane, Queensland, Australia

DOI: https://doi.org/10.1128/mBio.00324-21
Journal volume & issue: Vol. 12, no. 2

Abstract

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The bacterial second messenger cyclic di-AMP (c-di-AMP) is a global regulator of potassium homeostasis and compatible solute uptake in many Gram-positive bacteria, making it essential for osmoregulation. The role that c-di-AMP plays in β-lactam resistance, however, is unclear despite being first identified a decade ago.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

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