Injury of renal epithelial cell and the formation of Randall's plaque in kidney stones

Abstract

Kidney stone has a high incidence and recurrence rate, which is one of the common diseases in urology.At present, Randall's plaque theory is a widely accepted mechanism for the formation of kidney stones. Studies on Randall's plaque are of great significance for the prevention and treatment of kidney stones. Renal epithelial cell damage promotes the formation of Randall's plaque.In this paper, the research progress of osteogenic changes in renal epithelial cells, reactive oxygen species and oxidative stress, phagocytosis of macrophages, and non-coding RNA changes are reviewed.

Keywords

• randall's plaque| osteoblastic changes| macrophages| reactive oxygen species| inflammation