Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects

Fausto Almeida; Julie M. Wolf; Thiago Aparecido da Silva; Carlos M. DeLeon-Rodriguez; Caroline Patini Rezende; André Moreira Pessoni; Fabrício Freitas Fernandes; Rafael Silva-Rocha; Roberto Martinez; Marcio L. Rodrigues; Maria Cristina Roque-Barreira; Arturo Casadevall

doi:10.1038/s41467-017-02126-7

Nature Communications (Dec 2017)

Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects

Fausto Almeida,
Julie M. Wolf,
Thiago Aparecido da Silva,
Carlos M. DeLeon-Rodriguez,
Caroline Patini Rezende,
André Moreira Pessoni,
Fabrício Freitas Fernandes,
Rafael Silva-Rocha,
Roberto Martinez,
Marcio L. Rodrigues,
Maria Cristina Roque-Barreira,
Arturo Casadevall

Affiliations

Fausto Almeida: Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of Sao Paulo
Julie M. Wolf: Department of Microbiology and Immunology, Albert Einstein College of Medicine, Yeshiva University
Thiago Aparecido da Silva: Department of Cellular and Molecular Biology, Ribeirao Preto Medical School, University of Sao Paulo
Carlos M. DeLeon-Rodriguez: Department of Microbiology and Immunology, Albert Einstein College of Medicine, Yeshiva University
Caroline Patini Rezende: Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of Sao Paulo
André Moreira Pessoni: Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of Sao Paulo
Fabrício Freitas Fernandes: Department of Cellular and Molecular Biology, Ribeirao Preto Medical School, University of Sao Paulo
Rafael Silva-Rocha: Department of Cellular and Molecular Biology, Ribeirao Preto Medical School, University of Sao Paulo
Roberto Martinez: Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo
Marcio L. Rodrigues: Instituto de Microbiologia Paulo de Goes,, Universidade Federal do Rio de Janeiro
Maria Cristina Roque-Barreira: Department of Cellular and Molecular Biology, Ribeirao Preto Medical School, University of Sao Paulo
Arturo Casadevall: Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health

DOI: https://doi.org/10.1038/s41467-017-02126-7
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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The protein Galectin-3 modulates host immunity and plays roles during infections. Here, Almeida et al. show that this protein contributes to host defence against infection with the fungal pathogen Cryptococcus neoformans by inhibiting fungal growth and inducing lysis of fungal extracellular vesicles.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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