Fractional response analysis reveals logarithmic cytokine responses in cellular populations

Karol Nienałtowski; Rachel E. Rigby; Jarosław Walczak; Karolina E. Zakrzewska; Edyta Głów; Jan Rehwinkel; Michał Komorowski

doi:10.1038/s41467-021-24449-2

Nature Communications (Jul 2021)

Fractional response analysis reveals logarithmic cytokine responses in cellular populations

Karol Nienałtowski,
Rachel E. Rigby,
Jarosław Walczak,
Karolina E. Zakrzewska,
Edyta Głów,
Jan Rehwinkel,
Michał Komorowski

Affiliations

Karol Nienałtowski: Institute of Fundamental Technological Research, Polish Academy of Sciences
Rachel E. Rigby: Medical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
Jarosław Walczak: Institute of Fundamental Technological Research, Polish Academy of Sciences
Karolina E. Zakrzewska: Institute of Fundamental Technological Research, Polish Academy of Sciences
Edyta Głów: Institute of Fundamental Technological Research, Polish Academy of Sciences
Jan Rehwinkel: Medical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
Michał Komorowski: Institute of Fundamental Technological Research, Polish Academy of Sciences

DOI: https://doi.org/10.1038/s41467-021-24449-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 10

Abstract

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Our ability to interpret single-cell multivariate signaling responses is still limited. Here the authors introduce fractional response analysis (FRA), involving fractional cell counting, capable of deconvoluting heterogeneous multivariate responses of cellular populations.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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