Severe Multisystem Inflammatory Symptoms in 2 Adults after Short Interval between COVID-19 and Subsequent Vaccination

Abstract

We observed multisystem inflammatory syndrome in 2 older adults in the United States who had received mRNA coronavirus disease vaccine soon after natural infection. We identified 5 similar cases from the Vaccine Adverse Events Reporting System. The timing of vaccination soon after natural infection might have an adverse effect on the occurrence of vaccine-related systemic inflammatory disorders.

Keywords

• COVID-19
• multisystem inflammatory syndrome in adults
• MIS-A
• coronavirus disease
• SARS-CoV-2
• severe acute respiratory syndrome coronavirus 2