International Journal of Endocrinology (Jan 2019)

Polymorphisms in Adipokines in Mexican Children with Obesity

  • Angélica Saraí Jiménez-Osorio,
  • Alma Olivia Aguilar-Lucio,
  • Helios Cárdenas-Hernández,
  • Claudette Musalem-Younes,
  • Jacqueline Solares-Tlapechco,
  • Paula Costa-Urrutia,
  • Oscar Medina-Contreras,
  • Julio Granados,
  • Martha Eunice Rodríguez-Arellano

DOI
https://doi.org/10.1155/2019/4764751
Journal volume & issue
Vol. 2019

Abstract

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The high prevalence of childhood obesity in Mexico is alarming in the health-science field. We propose to investigate the contribution of adipokines and cytokines polymorphisms and common BMI/obesity-associated loci, revealed in genome-wide association studies in Caucasian adult cohorts, with childhood obesity. This study included 773 Mexican-Mestizo children (5-15 years old) in a case-control study. The polymorphisms included were ADIPOQ (rs6444174), TNF-α (rs1800750), IL-1β (rs1143643), IL-6 (rs1524107; rs2069845), NEGR1 (rs34305371), SEC16B-RASAL2 (rs10913469), TMEM18 (rs6548238; rs7561317), GNPDA2 (rs16857402), LEP (rs2167270), MTCH2 (rs10838738), LGR4-LIN7C-BDNF (rs925946), BCDIN3D-FAIM2 (rs7138803), FTO (rs62033400), MC4R (rs11872992), MC4R (rs17782313), and KCTD15 (rs29942). No significant contribution was found with adipokines and cytokines polymorphisms in this study. Only both TMEM18 (rs6548238; rs7561317) polymorphisms were found associated with obesity (OR=0.5, P=0.008) and were in linkage disequilibrium (r2=0.87). The linear regression showed that the rs7561317 polymorphism of TMEM18 is negatively associated with obesity. This report highlights the influence of TMEM18 in Mexican-Mestizo children obesity, while adipokine and cytokine polymorphisms were not associated with it.