Vaccines and Therapeutics Against Hantaviruses

Rongrong Liu; Hongwei Ma; Jiayi Shu; Jiayi Shu; Qiang Zhang; Mingwei Han; Ziyu Liu; Xia Jin; Fanglin Zhang; Xingan Wu

doi:10.3389/fmicb.2019.02989

Frontiers in Microbiology (Jan 2020)

Vaccines and Therapeutics Against Hantaviruses

Rongrong Liu,
Hongwei Ma,
Jiayi Shu,
Jiayi Shu,
Qiang Zhang,
Mingwei Han,
Ziyu Liu,
Xia Jin,
Fanglin Zhang,
Xingan Wu

Affiliations

Rongrong Liu: Department of Microbiology, School of Basic Medicine, Fourth Military Medical University, Xi’an, China
Hongwei Ma: Department of Microbiology, School of Basic Medicine, Fourth Military Medical University, Xi’an, China
Jiayi Shu: Scientific Research Center, Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education & Health, Shanghai Medical College, Fudan University, Shanghai, China
Jiayi Shu: Viral Disease and Vaccine Translational Research Unit, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China
Qiang Zhang: School of Biology and Basic Medical Sciences, Soochow University, Suzhou, China
Mingwei Han: Cadet Brigade, School of Basic Medicine, Fourth Military Medical University, Xi’an, China
Ziyu Liu: Department of Microbiology, School of Basic Medicine, Fourth Military Medical University, Xi’an, China
Xia Jin: Scientific Research Center, Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education & Health, Shanghai Medical College, Fudan University, Shanghai, China
Fanglin Zhang: Department of Microbiology, School of Basic Medicine, Fourth Military Medical University, Xi’an, China
Xingan Wu: Department of Microbiology, School of Basic Medicine, Fourth Military Medical University, Xi’an, China

DOI: https://doi.org/10.3389/fmicb.2019.02989
Journal volume & issue: Vol. 10

Abstract

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Hantaviruses (HVs) are rodent-transmitted viruses that can cause hantavirus cardiopulmonary syndrome (HCPS) in the Americas and hemorrhagic fever with renal syndrome (HFRS) in Eurasia. Together, these viruses have annually caused approximately 200,000 human infections worldwide in recent years, with a case fatality rate of 5–15% for HFRS and up to 40% for HCPS. There is currently no effective treatment available for either HFRS or HCPS. Only whole virus inactivated vaccines against HTNV or SEOV are licensed for use in the Republic of Korea and China, but the protective efficacies of these vaccines are uncertain. To a large extent, the immune correlates of protection against hantavirus are not known. In this review, we summarized the epidemiology, virology, and pathogenesis of four HFRS-causing viruses, HTNV, SEOV, PUUV, and DOBV, and two HCPS-causing viruses, ANDV and SNV, and then discussed the existing knowledge on vaccines and therapeutics against these diseases. We think that this information will shed light on the rational development of new vaccines and treatments.

Published in Frontiers in Microbiology

ISSN: 1664-302X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.frontiersin.org/journals/microbiology

About the journal

Abstract

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