Articular cartilage repair biomaterials: strategies and applications

Mingkai Wang; Yan Wu; Guangfeng Li; Qiushui Lin; Wencai Zhang; Han Liu; Jiacan Su

Materials Today Bio (Feb 2024)

Articular cartilage repair biomaterials: strategies and applications

Mingkai Wang,
Yan Wu,
Guangfeng Li,
Qiushui Lin,
Wencai Zhang,
Han Liu,
Jiacan Su

Affiliations

Mingkai Wang: Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; Organoid Research Center, Shanghai University, Shanghai, 200444, China; College of Medicine, Shanghai University, Shanghai, 200444, China
Yan Wu: Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; Organoid Research Center, Shanghai University, Shanghai, 200444, China
Guangfeng Li: Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; Organoid Research Center, Shanghai University, Shanghai, 200444, China; College of Medicine, Shanghai University, Shanghai, 200444, China; Department of Orthopedics Trauma, Shanghai Zhongye Hospital, Shanghai, 200941, China
Qiushui Lin: Department of Spine Surgery, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China; Corresponding author.
Wencai Zhang: Department of Orthopedics, The First Affiliated Hospital Jinan University, Guangzhou, 510632, China; Corresponding author.
Han Liu: Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; Organoid Research Center, Shanghai University, Shanghai, 200444, China; Corresponding author. Organoid Research Center, Shanghai University, Shanghai, 200444, China.
Jiacan Su: Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; Organoid Research Center, Shanghai University, Shanghai, 200444, China; Department of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China; Corresponding author. Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China.

Journal volume & issue: Vol. 24
p. 100948

Abstract

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Articular cartilage injury is a frequent worldwide disease, while effective treatment is urgently needed. Due to lack of blood vessels and nerves, the ability of cartilage to self-repair is limited. Despite the availability of various clinical treatments, unfavorable prognoses and complications remain prevalent. However, the advent of tissue engineering and regenerative medicine has generated considerable interests in using biomaterials for articular cartilage repair. Nevertheless, there remains a notable scarcity of comprehensive reviews that provide an in-depth exploration of the various strategies and applications. Herein, we present an overview of the primary biomaterials and bioactive substances from the tissue engineering perspective to repair articular cartilage. The strategies include regeneration, substitution, and immunization. We comprehensively delineate the influence of mechanically supportive scaffolds on cellular behavior, shedding light on emerging scaffold technologies, including stimuli-responsive smart scaffolds, 3D-printed scaffolds, and cartilage bionic scaffolds. Biologically active substances, including bioactive factors, stem cells, extracellular vesicles (EVs), and cartilage organoids, are elucidated for their roles in regulating the activity of chondrocytes. Furthermore, the composite bioactive scaffolds produced industrially to put into clinical use, are also explicitly presented. This review offers innovative solutions for treating articular cartilage ailments and emphasizes the potential of biomaterials for articular cartilage repair in clinical translation.

Published in Materials Today Bio

ISSN: 2590-0064 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General); Science: Biology (General)
Website: https://www.journals.elsevier.com/materials-today-bio

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