Research progress of IL⁃33/ST2 signaling pathway in bone metabolism

Abstract

Interleukin⁃33(IL⁃33) is a new member of the interleukin⁃1 (IL⁃1) cytokine superfamily. It can activate mast cells, lymphocytes and macrophages to produce Th2 cytokines and plays a very important role in inflammation, in⁃ fection, and autoimmune disease. The classical signal pathway of IL⁃33 includes the isotrimer of ST2 and interleukin⁃1 receptor accessory protein (IL⁃1 RAcP), which transduces signals into cells. The IL⁃33/ST2 signaling pathway affects bone metabolism by activating T and B lymphocytes. This article reviews the role of the IL⁃33/ST2 signaling pathway in bone metabolism. The results of a literature review showed that at present, scholars at home and abroad still dispute the role of IL⁃33 in bone metabolism. Some scholars believe that IL⁃33 can inhibit osteoclast formation, and IL⁃33 has been recently implicated in physiological bone remodeling. However, other scholars believe that IL⁃33 can promote osteoclast formation and differentiation, which leads to bone absorption. IL⁃33 and its signaling pathway are involved in bone me⁃ tabolism of alveolar bone in periodontitis and periapical periodontitis. The specific mechanism remains unclear, and fur⁃ ther studies are warranted.

Keywords

• IL⁃33，
• ST2，
• Osteoclast，
• Osteoblast，
• Bone metabolism，
• Interleukin⁃1 receptor accessory pro⁃ tein，
• Periodontitis，
• Periapical periodontitis，