Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity

Xing Xiao; Gagik Yeghiazaryan; Simon Hess; Paul Klemm; Anna Sieben; André Kleinridders; Donald A. Morgan; F. Thomas Wunderlich; Kamal Rahmouni; Dong Kong; Thomas E. Scammell; Bradford B. Lowell; Peter Kloppenburg; Jens C. Brüning; A. Christine Hausen

doi:10.1038/s41467-021-25380-2

Nature Communications (Sep 2021)

Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity

Xing Xiao,
Gagik Yeghiazaryan,
Simon Hess,
Paul Klemm,
Anna Sieben,
André Kleinridders,
Donald A. Morgan,
F. Thomas Wunderlich,
Kamal Rahmouni,
Dong Kong,
Thomas E. Scammell,
Bradford B. Lowell,
Peter Kloppenburg,
Jens C. Brüning,
A. Christine Hausen

Affiliations

Xing Xiao: Max Planck Institute for Metabolism Research, Department of Neuronal Control of Metabolism
Gagik Yeghiazaryan: Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne
Simon Hess: Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne
Paul Klemm: Max Planck Institute for Metabolism Research, Department of Neuronal Control of Metabolism
Anna Sieben: Max Planck Institute for Metabolism Research, Department of Neuronal Control of Metabolism
André Kleinridders: Max Planck Institute for Metabolism Research, Department of Neuronal Control of Metabolism
Donald A. Morgan: Department of Neuroscience and Pharmacology, University of Iowa, Carver College of Medicine
F. Thomas Wunderlich: Max Planck Institute for Metabolism Research, Department of Neuronal Control of Metabolism
Kamal Rahmouni: Department of Neuroscience and Pharmacology, University of Iowa, Carver College of Medicine
Dong Kong: Division of Endocrinology, Department of Pediatrics, F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Harvard Medical School
Thomas E. Scammell: Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School
Bradford B. Lowell: Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School
Peter Kloppenburg: Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne
Jens C. Brüning: Max Planck Institute for Metabolism Research, Department of Neuronal Control of Metabolism
A. Christine Hausen: Max Planck Institute for Metabolism Research, Department of Neuronal Control of Metabolism

DOI: https://doi.org/10.1038/s41467-021-25380-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 20

Abstract

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The wake-active orexin system plays a central role in the dynamic regulation of glucose homeostasis. Here the authors report that inactivation of the orexin receptor type 1 or 2 in serotonergic neurons differentially regulate systemic glucose homeostasis in the context of diet induced obesity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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