THE GENES ASSOCIATED WITH LIPID METABOLISM DISORDERS AND WITH BLOOD PRESSURE REGULATION, AND PSYCHOVEGETATIVE CHANGES IN THE YOUNG ALMOST HEALTHY PERSONS

Abstract

Aim. To assess the relation of polymorphism of the genes APOC3, PON1, AGT, AGTR1 and psychovegetative disorders in young, relatively healthy persons.Material and methods. Totally, 75 healthy volunteers included, white race, aged 20-25 y.o. Psychovegetative status was assessed with tests for panic attacks revealing, anxiety level assessment, as with the questionnaire for vegetovascular dystony. The inclusion criteria was organic pathology of cardiovascular and central nervous system. Genes polymorphism was identified with the method of pyrosequencing of desoxyribonucleic acid with the genetic analysis equipment “PyroMark Q24”Results. The presence of vegetovascular dystony, panic attacks and increased level of anxiety was mostly associated with the presence of T polymorphism -482 C>T gene APOC3, allele М polymorphism L55M А>Т gene PON1 and allele А — polymorphism А1666С А>С gene AGTR1. Conclusion. There is relation of genes polymorphism playing role in lipids metabolism and arterial pressure regulation, with psychovegetative status of the young, relatively healthy persons.

Keywords

• генетический полиморфизм
• панические атаки
• вегетативная дистония