Nature Communications (May 2017)

Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming

  • Marcial Camacho,
  • Jayeeta Basu,
  • Thorsten Trimbuch,
  • Shuwen Chang,
  • Cristina Pulido-Lozano,
  • Shwu-Shin Chang,
  • Irina Duluvova,
  • Masin Abo-Rady,
  • Josep Rizo,
  • Christian Rosenmund

DOI
https://doi.org/10.1038/ncomms15293
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

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The interaction between RIM and the C2A domain of Munc13 is known to be required for synaptic vesicle priming. Here the authors show new implications of the C2A domain of Munc13, through its dynamic interaction with RIM, in orchestrating a wide range of modulatory operations that shape vesicle docking, priming and neurotransmitter release.