Química Nova (Jan 2012)

Rotenoids from Tephrosia toxicaria with larvicidal activity against Aedes aegypti, the main vector of dengue fever

  • Jackson Nunes e Vasconcelos,
  • Gilvandete Maria Pinheiro Santiago,
  • Jefferson Queiroz Lima,
  • Jair Mafezoli,
  • Telma Leda Gomes de Lemos,
  • Francisca Renata Lopes da Silva,
  • Mary Anne Sousa Lima,
  • Antônia Torres Ávila Pimenta,
  • Raimundo Braz-Filho,
  • Angela Martha Campos Arriaga,
  • Dari Cesarin-Sobrinho

DOI
https://doi.org/10.1590/S0100-40422012000600005
Journal volume & issue
Vol. 35, no. 6
pp. 1097 – 1100

Abstract

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In the search for new larvicides from plants, we have investigated the potential activity of the rotenoids deguelin (1), 12a-hydroxy-α-toxicarol (2) and tephrosin (3), isolated from the bioactive ethanol extract of roots of Tephrosia toxicaria Pers., against Aedes aegypti, the main vector of dengue. The absolute configuration of these compounds was determined by circular dichroism (CD) spectra. The LC50 values of the compounds evaluated justify the potential of T. toxicaria as a new natural larvicide.

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