Circadian control of brain glymphatic and lymphatic fluid flow

Lauren M. Hablitz; Virginia Plá; Michael Giannetto; Hanna S. Vinitsky; Frederik Filip Stæger; Tanner Metcalfe; Rebecca Nguyen; Abdellatif Benrais; Maiken Nedergaard

doi:10.1038/s41467-020-18115-2

Nature Communications (Sep 2020)

Circadian control of brain glymphatic and lymphatic fluid flow

Lauren M. Hablitz,
Virginia Plá,
Michael Giannetto,
Hanna S. Vinitsky,
Frederik Filip Stæger,
Tanner Metcalfe,
Rebecca Nguyen,
Abdellatif Benrais,
Maiken Nedergaard

Affiliations

Lauren M. Hablitz: Center for Translational Neuromedicine, University of Rochester Medical Center
Virginia Plá: Center for Translational Neuromedicine, University of Rochester Medical Center
Michael Giannetto: Center for Translational Neuromedicine, University of Rochester Medical Center
Hanna S. Vinitsky: Center for Translational Neuromedicine, University of Rochester Medical Center
Frederik Filip Stæger: Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen
Tanner Metcalfe: Center for Translational Neuromedicine, University of Rochester Medical Center
Rebecca Nguyen: Center for Translational Neuromedicine, University of Rochester Medical Center
Abdellatif Benrais: Center for Translational Neuromedicine, University of Rochester Medical Center
Maiken Nedergaard: Center for Translational Neuromedicine, University of Rochester Medical Center

DOI: https://doi.org/10.1038/s41467-020-18115-2
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

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Glymphatic function is increased during the rest phase while more cerebrospinal fluid (CSF) drains directly to the lymphatic system during the active phase. The water channel aquaporin-4 supports these endogenous, circadian rhythms in CSF distribution.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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