Communications Biology (Sep 2022)

Single nuclei transcriptomics of muscle reveals intra-muscular cell dynamics linked to dystrophin loss and rescue

  • Deirdre D. Scripture-Adams,
  • Kevin N. Chesmore,
  • Florian Barthélémy,
  • Richard T. Wang,
  • Shirley Nieves-Rodriguez,
  • Derek W. Wang,
  • Ekaterina I. Mokhonova,
  • Emilie D. Douine,
  • Jijun Wan,
  • Isaiah Little,
  • Laura N. Rabichow,
  • Stanley F. Nelson,
  • M. Carrie Miceli

DOI
https://doi.org/10.1038/s42003-022-03938-0
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 14

Abstract

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A method to isolate and sequence individual nuclei from human and mouse muscle biopsies provides further insight into the mechanisms of dystrophin loss and repair, in the context of Duchenne muscular dystrophy.