Nature Communications (Mar 2023)
Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer’s disease
- Byung Jo Choi,
- Min Hee Park,
- Kang Ho Park,
- Wan Hui Han,
- Hee Ji Yoon,
- Hye Yoon Jung,
- Ju Yeon Hong,
- Md Riad Chowdhury,
- Kyung Yeol Kim,
- Jihoon Lee,
- Im-Sook Song,
- Minyeong Pang,
- Min-Koo Choi,
- Erich Gulbins,
- Martin Reichel,
- Johannes Kornhuber,
- Chang-Won Hong,
- Changho Kim,
- Seung Hyun Kim,
- Edward H. Schuchman,
- Hee Kyung Jin,
- Jae-sung Bae
Affiliations
- Byung Jo Choi
- KNU Alzheimer’s disease Research Institute, Kyungpook National University
- Min Hee Park
- KNU Alzheimer’s disease Research Institute, Kyungpook National University
- Kang Ho Park
- KNU Alzheimer’s disease Research Institute, Kyungpook National University
- Wan Hui Han
- KNU Alzheimer’s disease Research Institute, Kyungpook National University
- Hee Ji Yoon
- KNU Alzheimer’s disease Research Institute, Kyungpook National University
- Hye Yoon Jung
- KNU Alzheimer’s disease Research Institute, Kyungpook National University
- Ju Yeon Hong
- KNU Alzheimer’s disease Research Institute, Kyungpook National University
- Md Riad Chowdhury
- KNU Alzheimer’s disease Research Institute, Kyungpook National University
- Kyung Yeol Kim
- KNU Alzheimer’s disease Research Institute, Kyungpook National University
- Jihoon Lee
- BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit, Vessel-Organ Interaction Research Center (VOICE), College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University
- Im-Sook Song
- BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit, Vessel-Organ Interaction Research Center (VOICE), College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University
- Minyeong Pang
- College of Pharmacy, Dankook University
- Min-Koo Choi
- College of Pharmacy, Dankook University
- Erich Gulbins
- Department of Molecular Biology, University of Duisburg-Essen
- Martin Reichel
- Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University of Erlangen-Nuremberg
- Johannes Kornhuber
- Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University of Erlangen-Nuremberg
- Chang-Won Hong
- Department of Physiology, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University
- Changho Kim
- Department of Emergency Medicine, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University
- Seung Hyun Kim
- Department of Neurology, Hanyang University College of Medicine
- Edward H. Schuchman
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Hee Kyung Jin
- KNU Alzheimer’s disease Research Institute, Kyungpook National University
- Jae-sung Bae
- KNU Alzheimer’s disease Research Institute, Kyungpook National University
- DOI
- https://doi.org/10.1038/s41467-023-37316-z
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 17
Abstract
Acid sphingomyelinase (ASM) is a sphingolipid metabolizing enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide, and previous work has shown it is upregulated in models of Alzheimer’s disease. Here the authors demonstrate in a mouse model of Alzheimer’s disease that antibody-based immunotherapy targeting plasma ASM resulted in attenuated neuropathological features by suppressing pathogenic Th17 cells.
