Nature Communications (Feb 2019)
Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations
- Michelle Daya,
- Nicholas Rafaels,
- Tonya M. Brunetti,
- Sameer Chavan,
- Albert M. Levin,
- Aniket Shetty,
- Christopher R. Gignoux,
- Meher Preethi Boorgula,
- Genevieve Wojcik,
- Monica Campbell,
- Candelaria Vergara,
- Dara G. Torgerson,
- Victor E. Ortega,
- Ayo Doumatey,
- Henry Richard Johnston,
- Nathalie Acevedo,
- Maria Ilma Araujo,
- Pedro C. Avila,
- Gillian Belbin,
- Eugene Bleecker,
- Carlos Bustamante,
- Luis Caraballo,
- Alvaro Cruz,
- Georgia M. Dunston,
- Celeste Eng,
- Mezbah U. Faruque,
- Trevor S. Ferguson,
- Camila Figueiredo,
- Jean G. Ford,
- Weiniu Gan,
- Pierre-Antoine Gourraud,
- Nadia N. Hansel,
- Ryan D. Hernandez,
- Edwin Francisco Herrera-Paz,
- Silvia Jiménez,
- Eimear E. Kenny,
- Jennifer Knight-Madden,
- Rajesh Kumar,
- Leslie A. Lange,
- Ethan M. Lange,
- Antoine Lizee,
- Pissamai Maul,
- Trevor Maul,
- Alvaro Mayorga,
- Deborah Meyers,
- Dan L. Nicolae,
- Timothy D. O’Connor,
- Ricardo Riccio Oliveira,
- Christopher O. Olopade,
- Olufunmilayo Olopade,
- Zhaohui S. Qin,
- Charles Rotimi,
- Nicolas Vince,
- Harold Watson,
- Rainford J. Wilks,
- James G. Wilson,
- Steven Salzberg,
- Carole Ober,
- Esteban G. Burchard,
- L. Keoki Williams,
- Terri H. Beaty,
- Margaret A. Taub,
- Ingo Ruczinski,
- Rasika A. Mathias,
- Kathleen C. Barnes,
- CAAPA
Affiliations
- Michelle Daya
- Department of Medicine, University of Colorado Denver
- Nicholas Rafaels
- Department of Medicine, University of Colorado Denver
- Tonya M. Brunetti
- Department of Medicine, University of Colorado Denver
- Sameer Chavan
- Department of Medicine, University of Colorado Denver
- Albert M. Levin
- Department of Public Health Sciences, Henry Ford Health System
- Aniket Shetty
- Department of Medicine, University of Colorado Denver
- Christopher R. Gignoux
- Department of Medicine, University of Colorado Denver
- Meher Preethi Boorgula
- Department of Medicine, University of Colorado Denver
- Genevieve Wojcik
- Department of Genetics, Stanford University School of Medicine
- Monica Campbell
- Department of Medicine, University of Colorado Denver
- Candelaria Vergara
- Department of Medicine, Johns Hopkins University
- Dara G. Torgerson
- Department of Medicine, University of California San Francisco
- Victor E. Ortega
- Center for Human Genomics and Personalized Medicine, Wake Forest School of Medicine
- Ayo Doumatey
- Center for Research on Genomics & Global Health, National Institutes of Health
- Henry Richard Johnston
- Department of Human Genetics, Emory University
- Nathalie Acevedo
- Institute for Immunological Research, Universidad de Cartagena
- Maria Ilma Araujo
- Immunology Service, Universidade Federal da Bahia
- Pedro C. Avila
- Department of Medicine, Northwestern University
- Gillian Belbin
- Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai
- Eugene Bleecker
- Department of Medicine, University of Arizona College of Medicine
- Carlos Bustamante
- Department of Genetics, Stanford University School of Medicine
- Luis Caraballo
- Institute for Immunological Research, Universidad de Cartagena
- Alvaro Cruz
- Universidade Federal da Bahia
- Georgia M. Dunston
- Department of Microbiology, Howard University College of Medicine
- Celeste Eng
- Department of Medicine, University of California San Francisco
- Mezbah U. Faruque
- National Human Genome Center, Howard University College of Medicine
- Trevor S. Ferguson
- Caribbean Institute for Health Research, The University of the West Indies
- Camila Figueiredo
- Departamento de Biorregulacao, Universidade Federal da Bahia
- Jean G. Ford
- Department of Medicine, Einstein Medical Center
- Weiniu Gan
- National Heart, Lung and Blood Institute, National Institutes of Health
- Pierre-Antoine Gourraud
- Université de Nantes, INSERM, Centre de Recherche en Transplantation et Immunologie, UMR
- Nadia N. Hansel
- Department of Medicine, Johns Hopkins University
- Ryan D. Hernandez
- Department of Bioengineering and Therapeutic Sciences, University of California San Francisco
- Edwin Francisco Herrera-Paz
- Facultad de Medicina, Universidad Católica de Honduras
- Silvia Jiménez
- Institute for Immunological Research, Universidad de Cartagena
- Eimear E. Kenny
- Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai
- Jennifer Knight-Madden
- Caribbean Institute for Health Research, The University of the West Indies
- Rajesh Kumar
- Department of Pediatrics, Northwestern University
- Leslie A. Lange
- Department of Medicine, University of Colorado Denver
- Ethan M. Lange
- Department of Medicine, University of Colorado Denver
- Antoine Lizee
- Université de Nantes, INSERM, Centre de Recherche en Transplantation et Immunologie, UMR
- Pissamai Maul
- Genetics and Epidemiology of Asthma in Barbados, The University of the West Indies, Chronic Disease Research Centre
- Trevor Maul
- Genetics and Epidemiology of Asthma in Barbados, The University of the West Indies, Chronic Disease Research Centre
- Alvaro Mayorga
- Centro de Neumologia y Alergias
- Deborah Meyers
- Department of Medicine, University of Arizona College of Medicine
- Dan L. Nicolae
- Department of Medicine, University of Chicago
- Timothy D. O’Connor
- Institute for Genome Sciences, University of Maryland School of Medicine
- Ricardo Riccio Oliveira
- Laboratório de Patologia Experimental, Centro de Pesquisas Gonçalo Moniz
- Christopher O. Olopade
- Department of Medicine and Center for Global Health, University of Chicago
- Olufunmilayo Olopade
- Department of Medicine, University of Chicago
- Zhaohui S. Qin
- Department of Biostatistics and Bioinformatics, Emory University
- Charles Rotimi
- Center for Research on Genomics & Global Health, National Institutes of Health
- Nicolas Vince
- Université de Nantes, INSERM, Centre de Recherche en Transplantation et Immunologie, UMR
- Harold Watson
- Faculty of Medical Sciences, The University of the West Indies, Queen Elizabeth Hospital
- Rainford J. Wilks
- Caribbean Institute for Health Research, The University of the West Indies
- James G. Wilson
- Department of Physiology and Biophysics, University of Mississippi Medical Center
- Steven Salzberg
- Departments of Biomedical Engineering and Biostatistics, Johns Hopkins University
- Carole Ober
- Department of Human Genetics, University of Chicago
- Esteban G. Burchard
- Department of Bioengineering and Therapeutic Sciences, University of California San Francisco
- L. Keoki Williams
- Center for Individualized and Genomic Medicine Research, Henry Ford Health System
- Terri H. Beaty
- Department of Epidemiology, Bloomberg School of Public Health, JHU
- Margaret A. Taub
- Department of Biostatistics, Bloomberg School of Public Health, JHU
- Ingo Ruczinski
- Department of Biostatistics, Bloomberg School of Public Health, JHU
- Rasika A. Mathias
- Department of Medicine, Johns Hopkins University
- Kathleen C. Barnes
- Department of Medicine, University of Colorado Denver
- CAAPA
- DOI
- https://doi.org/10.1038/s41467-019-08469-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
The burden of asthma varies between ancestries, but GWAS have so far focused on mainly European ancestry populations. Here, Daya et al. perform GWAS for asthma in 14,654 individuals of African ancestry and, besides confirming previously known loci, identify two potentially African ancestry-specific loci.
