Lipid peroxidation processes in women with chronic parenteral viral hepatitis

Abstract

Increased percentage of incidence of chronic parenteral viral hepatitis in women is an negative sign. The objective of this study was to identify features of the lipid peroxidation-antioxidant defense system in women of reproductive age with the chronic form of parenteral viral hepatitis depending on a degree of infection process activity. The study involved 44 women with chronic parenteral viral hepatitis (including 24 patients with minimum and low degrees of activity and 20 patients with moderate and high degrees of activity) and 28 healthy women of the same age. Spectrophotometric and fluorometric methods were used. Patients with minimum and low degrees of activity of chronic parenteral viral hepatitis had lower levels of diene conjugates - 22.6 % less, an increased TBA-reactive product level - 53.4 % less, reducing superoxide dismutase activity (21.2 %) compared with the control. In the group with moderate and high activities of chronic parenteral viral hepatitis TBA-reactive product level was increased by 2.3 times and superoxide dismutase activity was decreased by 20.7 % in comparison with the control. The chronic form of parenteral viral hepatitis was characterized by the series of metabolic disorders depending on the degree of inflammatory process activity. This requires a more careful approach to therapeutic and diagnostic activities.

Keywords

• lipid peroxidation
• antioxidant protection
• chronic viral hepatitis
• women
• reproductive age