TFEB regulates sulfur amino acid and coenzyme A metabolism to support hepatic metabolic adaptation and redox homeostasis

David Matye; Sumedha Gunewardena; Jianglei Chen; Huaiwen Wang; Yifeng Wang; Mohammad Nazmul Hasan; Lijie Gu; Yung Dai Clayton; Yanhong Du; Cheng Chen; Jacob E. Friedman; Shelly C. Lu; Wen-Xing Ding; Tiangang Li

doi:10.1038/s41467-022-33465-9

Nature Communications (Sep 2022)

TFEB regulates sulfur amino acid and coenzyme A metabolism to support hepatic metabolic adaptation and redox homeostasis

David Matye,
Sumedha Gunewardena,
Jianglei Chen,
Huaiwen Wang,
Yifeng Wang,
Mohammad Nazmul Hasan,
Lijie Gu,
Yung Dai Clayton,
Yanhong Du,
Cheng Chen,
Jacob E. Friedman,
Shelly C. Lu,
Wen-Xing Ding,
Tiangang Li

Affiliations

David Matye: Harold Hamm Diabetes Center, Department of Physiology, University of Oklahoma Health Sciences Center
Sumedha Gunewardena: Department of Cell Biology and Physiology, University of Kansas Medical Center
Jianglei Chen: Harold Hamm Diabetes Center, Department of Physiology, University of Oklahoma Health Sciences Center
Huaiwen Wang: Laboratory for Molecular Biology and Cytometry Research, University of Oklahoma Health Sciences Center
Yifeng Wang: Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center
Mohammad Nazmul Hasan: Harold Hamm Diabetes Center, Department of Physiology, University of Oklahoma Health Sciences Center
Lijie Gu: Harold Hamm Diabetes Center, Department of Physiology, University of Oklahoma Health Sciences Center
Yung Dai Clayton: Harold Hamm Diabetes Center, Department of Physiology, University of Oklahoma Health Sciences Center
Yanhong Du: Harold Hamm Diabetes Center, Department of Physiology, University of Oklahoma Health Sciences Center
Cheng Chen: Harold Hamm Diabetes Center, Department of Physiology, University of Oklahoma Health Sciences Center
Jacob E. Friedman: Harold Hamm Diabetes Center, Department of Physiology, University of Oklahoma Health Sciences Center
Shelly C. Lu: Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical Center
Wen-Xing Ding: Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center
Tiangang Li: Harold Hamm Diabetes Center, Department of Physiology, University of Oklahoma Health Sciences Center

DOI: https://doi.org/10.1038/s41467-022-33465-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

Read online

Matye el al. show that coenzyme-A and glutathione deficiency in NAFLD limits fatty acid oxidation and antioxidant defence capacity. The nutrient sensing transcription factor EB induces autophagy–lysosome proteolysis and methionine cycle-transsulfuration to maintain hepatic cysteine, coenzyme-A and glutathione availability.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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