Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy

James B. Whitney; So-Yon Lim; Christa E. Osuna; Jessica L. Kublin; Elsa Chen; Gyeol Yoon; Po-Ting Liu; Peter Abbink; Erica N. Borducci; Alison Hill; Mark G. Lewis; Romas Geleziunas; Merlin L. Robb; Nelson L. Michael; Dan H. Barouch

doi:10.1038/s41467-018-07881-9

Nature Communications (Dec 2018)

Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy

James B. Whitney,
So-Yon Lim,
Christa E. Osuna,
Jessica L. Kublin,
Elsa Chen,
Gyeol Yoon,
Po-Ting Liu,
Peter Abbink,
Erica N. Borducci,
Alison Hill,
Mark G. Lewis,
Romas Geleziunas,
Merlin L. Robb,
Nelson L. Michael,
Dan H. Barouch

Affiliations

James B. Whitney: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
So-Yon Lim: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Christa E. Osuna: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Jessica L. Kublin: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Elsa Chen: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Gyeol Yoon: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Po-Ting Liu: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Peter Abbink: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Erica N. Borducci: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Alison Hill: Program for Evolutionary Dynamics, Harvard University
Mark G. Lewis: Bioqual
Romas Geleziunas: Gilead Sciences
Merlin L. Robb: U.S. Military HIV Research Program, Henry Jackson Foundation
Nelson L. Michael: Walter Reed Army Institute of Research
Dan H. Barouch: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-018-07881-9
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 8

Abstract

Read online

The latent HIV-1 reservoir is the key obstacle for curing HIV-1 infection, but the timepoint at which the HIV-1 reservoir is established is currently unclear. Here, Whitney et al. show in non-human primates that the SIV reservoir in CD4+ T cells is seeded within the first 2 days after infection.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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