The attraction of paraoxonase-1 associated with the MAPK pathway on colon carcinoma cells

Abstract

A comprehensive understanding of the role of PON enzymatic activities may play an important role in the etiology and prevention of many cancers. PON1 is known as a potent antioxidant that scavenges free radicals in the human body. The enzymatic activities of paraoxonase (PON1) and mitogen-activated protein kinase (MAPK) signalling pathways in colorectal cancer are being investigated to determine whether they hold promise for novel diagnostic or therapeutic applications in colorectal cancer.

Keywords

• antioxidant
• colon cancer
• erk pathway
• oxidative stress
• paraoxonase-1