Nature Communications (Mar 2021)
An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism
- Marisa Nacke,
- Emma Sandilands,
- Konstantina Nikolatou,
- Álvaro Román-Fernández,
- Susan Mason,
- Rachana Patel,
- Sergio Lilla,
- Tamas Yelland,
- Laura C. A. Galbraith,
- Eva C. Freckmann,
- Lynn McGarry,
- Jennifer P. Morton,
- Emma Shanks,
- Hing Y. Leung,
- Elke Markert,
- Shehab Ismail,
- Sara Zanivan,
- Karen Blyth,
- David M. Bryant
Affiliations
- Marisa Nacke
- Institute of Cancer Sciences, University of Glasgow
- Emma Sandilands
- Institute of Cancer Sciences, University of Glasgow
- Konstantina Nikolatou
- Institute of Cancer Sciences, University of Glasgow
- Álvaro Román-Fernández
- Institute of Cancer Sciences, University of Glasgow
- Susan Mason
- The CRUK Beatson Institute
- Rachana Patel
- The CRUK Beatson Institute
- Sergio Lilla
- The CRUK Beatson Institute
- Tamas Yelland
- The CRUK Beatson Institute
- Laura C. A. Galbraith
- The CRUK Beatson Institute
- Eva C. Freckmann
- Institute of Cancer Sciences, University of Glasgow
- Lynn McGarry
- The CRUK Beatson Institute
- Jennifer P. Morton
- Institute of Cancer Sciences, University of Glasgow
- Emma Shanks
- The CRUK Beatson Institute
- Hing Y. Leung
- Institute of Cancer Sciences, University of Glasgow
- Elke Markert
- The CRUK Beatson Institute
- Shehab Ismail
- Institute of Cancer Sciences, University of Glasgow
- Sara Zanivan
- Institute of Cancer Sciences, University of Glasgow
- Karen Blyth
- Institute of Cancer Sciences, University of Glasgow
- David M. Bryant
- Institute of Cancer Sciences, University of Glasgow
- DOI
- https://doi.org/10.1038/s41467-021-21847-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 22
Abstract
The signalling pathways underpinning cell growth and invasion use overlapping components, yet how mutually exclusive responses occur is unclear. Here, the authors show that alternate isoforms of the ARF GTPase exchange factor IQSEC1 direct phosphoinositide metabolism to control this switch.
