Nature Communications (Apr 2018)
A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation
- Ewoud B. Compeer,
- Felix Kraus,
- Manuela Ecker,
- Gregory Redpath,
- Mayan Amiezer,
- Nils Rother,
- Philip R. Nicovich,
- Natasha Kapoor-Kaushik,
- Qiji Deng,
- Guerric P. B. Samson,
- Zhengmin Yang,
- Jieqiong Lou,
- Michael Carnell,
- Haig Vartoukian,
- Katharina Gaus,
- Jérémie Rossy
Affiliations
- Ewoud B. Compeer
- EMBL Australia Node in Single Molecule Science, School of Medical Sciences and the ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales
- Felix Kraus
- EMBL Australia Node in Single Molecule Science, School of Medical Sciences and the ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales
- Manuela Ecker
- EMBL Australia Node in Single Molecule Science, School of Medical Sciences and the ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales
- Gregory Redpath
- EMBL Australia Node in Single Molecule Science, School of Medical Sciences and the ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales
- Mayan Amiezer
- EMBL Australia Node in Single Molecule Science, School of Medical Sciences and the ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales
- Nils Rother
- EMBL Australia Node in Single Molecule Science, School of Medical Sciences and the ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales
- Philip R. Nicovich
- EMBL Australia Node in Single Molecule Science, School of Medical Sciences and the ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales
- Natasha Kapoor-Kaushik
- EMBL Australia Node in Single Molecule Science, School of Medical Sciences and the ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales
- Qiji Deng
- EMBL Australia Node in Single Molecule Science, School of Medical Sciences and the ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales
- Guerric P. B. Samson
- Biotechnology Institute Thurgau at the University of Konstanz
- Zhengmin Yang
- EMBL Australia Node in Single Molecule Science, School of Medical Sciences and the ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales
- Jieqiong Lou
- EMBL Australia Node in Single Molecule Science, School of Medical Sciences and the ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales
- Michael Carnell
- Biomedical Imaging Facility, University of New South Wales
- Haig Vartoukian
- EMBL Australia Node in Single Molecule Science, School of Medical Sciences and the ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales
- Katharina Gaus
- EMBL Australia Node in Single Molecule Science, School of Medical Sciences and the ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales
- Jérémie Rossy
- EMBL Australia Node in Single Molecule Science, School of Medical Sciences and the ARC Centre of Excellence in Advanced Molecular Imaging, University of New South Wales
- DOI
- https://doi.org/10.1038/s41467-018-04088-w
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
Endocytosis of T cell receptors (TCR) and their polarized recycling back to the plasma membrane is crucial for T cell activation; however, the underlying mechanisms remain unclear. Here the authors follow TCR and show that a mobile endocytic network connects clathrin-independent receptor endocytosis to recycling which is required for T cell activation.
