Pro-senescence neddylation inhibitor combined with a senescence activated β-galactosidase prodrug to selectively target cancer cells

• Shuaishuai Ni,
• Qian Liu,
• Xin Chen,
• Lele Ding,
• Lili Cai,
• Fei Mao,
• Donglei Shi,
• Robert M. Hoffman,
• Jian Li,
• Lijun Jia

Affiliations

Shuaishuai Ni

Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine

Qian Liu

Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine

Xin Chen

State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology

Lele Ding

Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine

Lili Cai

Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine

Fei Mao

State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology

Donglei Shi

State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology

Robert M. Hoffman

Department of Surgery, University of California

Jian Li

State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology

Lijun Jia

Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine