Assessment of Plasma Thiol-disulfide Balance in Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma

Abstract

INTRODUCTION[|]The thiol-disulfide balance is very important in cellular events such as apoptosis and oxidative stress. This study is a comparison of plasma thiol-disulfide homeostasis in patients with pseudoexfoliation syndrome (PEXS) and pseudoexfoliation glaucoma (PEXG).[¤]METHODS[|]Thirty-one patients with PEXS, 43 patients with PEXG, and 38 healthy controls were included in this prospective study. The plasma level of native thiol and disulfide were measured using a spectrophotometric assay and the native thiol/disulfide ratio was analyzed[¤]RESULTS[|]The demographic characteristics of the 3 groups were similar (p>0.05). Statistically significant differences were observed in the plasma disulfide levels (21.6+-7.3 µmol/L vs. 17.4+-6.8 µmol/L) and the native thiol/disulfide ratio (22.9+-9.1 vs. 29.9+-14.7) between the PEXG group and the controls (p=0.03, p=0.02, respectively).[¤]DISCUSSION AND CONCLUSION[|]Significant differences in the plasma levels of disulfide and the native thiol/disulfide ratio in PEXG patients indicated a breakdown of the thiol-disulfide circuits.[¤]

Keywords

• oxidative stress
• pseudoexfoliation syndrome
• pseudoexfoliation glaucoma
• thiol-disulfide balance.