ADAP1 promotes latent HIV-1 reactivation by selectively tuning KRAS–ERK–AP-1 T cell signaling-transcriptional axis

Abstract

By screening for host factors that influence HIV-1 proviral fate, the authors identified ADAP1 as a tuner of KRAS–ERK–AP-1 axis, which consequentially influences gene programs relevant for T cell activation and latent virus reactivation.