Nature Communications (Nov 2016)

Autophagy controls centrosome number by degrading Cep63

  • Yuichiro Watanabe,
  • Shinya Honda,
  • Akimitsu Konishi,
  • Satoko Arakawa,
  • Michiko Murohashi,
  • Hirofumi Yamaguchi,
  • Satoru Torii,
  • Minoru Tanabe,
  • Shinji Tanaka,
  • Eiji Warabi,
  • Shigeomi Shimizu

DOI
https://doi.org/10.1038/ncomms13508
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 12

Abstract

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The ubiquitin-proteasome system is thought to be the primary regulator of centrosome number. Here, Watanabe et al. show that selective autophagy also plays a role in regulating centrosome number via p62-dependent recruitment of centrosomal protein 63 to autophagosomes.