A distributive peptide cyclase processes multiple microviridin core peptides within a single polypeptide substrate

Yi Zhang; Kunhua Li; Guang Yang; Joshua L. McBride; Steven D. Bruner; Yousong Ding

doi:10.1038/s41467-018-04154-3

Nature Communications (May 2018)

A distributive peptide cyclase processes multiple microviridin core peptides within a single polypeptide substrate

Yi Zhang,
Kunhua Li,
Guang Yang,
Joshua L. McBride,
Steven D. Bruner,
Yousong Ding

Affiliations

Yi Zhang: Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development, College of Pharmacy, University of Florida
Kunhua Li: Department of Chemistry, University of Florida
Guang Yang: Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development, College of Pharmacy, University of Florida
Joshua L. McBride: Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development, College of Pharmacy, University of Florida
Steven D. Bruner: Department of Chemistry, University of Florida
Yousong Ding: Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development, College of Pharmacy, University of Florida

DOI: https://doi.org/10.1038/s41467-018-04154-3
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 10

Abstract

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Microviridins belong to the family of ribosomally synthesized and post-translationally modified peptides (RiPPs). Here, the authors discover a microviridin-synthesizing enzyme in a cyanobacterium that modifies multiple core peptides from a single substrate in a distributive and unstrictly directional manner, an unusual biosynthetic logic for RiPPs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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