Perspectives In Medical Research (Apr 2020)
Evaluation of Thyroid Function Status in Polycystic Ovary Syndrome
Abstract
Background: PCOS is very commonly seen in young females with chronic anovulatory cycles. It is manifested by features of hyperandrogenism, polycystic ovaries. The risk of insulin resistance is greater in patients with PCOS. There is also a greater incidence of type 2 diabetes, obesity and cardiovascular diseases in patients with PCOS. There are associated endocrinal abnormalities with PCOS most common of which include hypothyroidism. Therefore we in the present study tried to evaluate the existence of hypothyroidism in patients with PCOS in the patients reporting to our Hospital. Methods: The present study was conducted in the Department of Obstetrics and gynecology, MGM Hospital and Kakatiya Medical College, Warangal. Institutional Ethical committee permission was obtained for the study. The duration of the study was from January 2018 to May 2019. N=30 patients were detected with PCOS during the study period. A similar number of age-matched controls without PCOS were taken for comparison. Anthropometric measurements were made for BMI, waist-hip ratio calculation. TSH, FSH, LH, and Testosterone were estimated by Chemiluminescence ImmunoAssay (CLIA) technique. Results: The Mean Bodyweight 62.17 Vs 49.33 Kgs, The mean BMI was 24.03 Vs 22.48 Kg/m2. The mean TSH values were 5.33 Vs 2.51 µIU/ml. The mean FSH values were 12.27 Vs 8.49 µIU/ml the mean LH was 4.27 Vs 10.49 µIU/ml and the mean Testosterone levels were 69.73 Vs 9.28 ng/ml. Conclusion: The present study concludes that patients with PCOS have a greater frequency of thyroid dysfunctions including other endocrinal abnormalities. Accordingly, those diagnosed with PCOS must undergo complete endocrinal investigations. This can help to identify the co-existing endocrinal abnormalities and treatment is given accordingly to prevent morbidity and mortality
