TOXICOLOGIC CHARACTERISTICS OF THE PREVENTIVE IODINE-CONTAINING PREPARATION “VANGTSEYOD”

Abstract

The Amur Oblast belongs to biogeochemical province with low contents of iodine in the soil, water and air, which leads to the thyroid gland disorders in animals, weakened immunity system and, consequently, to the increased sensitivity to diseases. A new iodinecontaining preparation “Vangtseyod” has been developed basing on natural zeolites from Vanga deposits to prevent iodine deficit in young cattle. The distinctive feature of the Vanga deposit zeolite in comparison with other deposits of the Amur Oblast and the Far East is that it contains more effective clinoptilolite and heulandite minerals, characterized by the low contents of harmful compounds. Studies of the preparation safety performed on white mice showed that “Vangtseyod” does not have acute toxicity. It’s inclusion into mice diet at 1.0 and 2.0 g/kg dose during two months did not induce any signs of chronic intoxication as 100% mice of experimental group survived in comparison with the control group (57%). Feeding mice with the preparation at 1.0 g/kg dose facilitated improved protein and carbohydrate metabolism.

Keywords

• iodine insufficiency
• weakening of the immune system
• preventive iodine-containing preparation