Bezmiâlem Science (Apr 2017)

Relationships Among Markers of Inflammation, Neutrophil-to-Lymphocyte Ratio, and Syntax Severity Score in the Early Phase of Acute Coronary Syndrome

  • Ali DUR,
  • Ziya İSMAİLOĞLU,
  • Medine İSMAİLOVA,
  • Dursun AKBAY,
  • Ömer UYSAL,
  • Hüseyin METİN,
  • Bedia GÜLEN,
  • Ertan SÖNMEZ

DOI
https://doi.org/10.14235/bs.2016.790
Journal volume & issue
Vol. 5, no. 2
pp. 56 – 60

Abstract

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Objective:The aim of the present study was to examine a possible association between inflammation, as indicated by High-sensitivity C-reactive protein (HsCRP) and neutrophil/ lymphocyte ratio (NLR), and the complexity and severity of coronary artery disease assessed using syntax severity score (SSS) in patients with acute coronary syndrome (ACS).Methods:Patients with symptoms suggestive of ACS who were admitted within 6 h of onset and who underwent coronary angiography were enrolled in the study. According to NLR, we divided patients into two groups: group 1 (NLR≤2.7) and group 2 (NLR>2.7). According to SSS, patients were divided into two groups: group 1 including low scores and group 2 including intermediate and high scores. Statistical analysis was performed using chi-square test and Mann–Whitney U test.Results:A total of 87 patients (65 males and 22 females) with acute myocardial infarction (AMI; 57 ST-se AMI and 30 non-ST-se AMI) were included in this study. Patients were classified into low (NLR≤2.7, n=63) and high (NLR>2.7, n=24) NLR groups. Univariate a>nalysis demonstrated that SSS was significantly higher in high NLR group than in low NLR group (23.6±12.7 versus 13.9±8.7, p<0.001). Similar to NLR, significant correlation was revealed among HsCRP, troponin levels, and SSS that indicated their predictive value in the severity of AMI.Conclusion:In present study, we showed NLR to be an independent predictor of hemodynamically significant coronary artery stenosis as measured using SSS.

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