Genome-wide perturbations of Alu expression and Alu-associated post-transcriptional regulations distinguish oligodendroglioma from other gliomas

Abstract

Taeyoung Hwang et al. evaluate the relevance of Alu repeat elements to gliomagenesis using transcriptomic data from 41 pairs of neurotypical and diverse glioma brain tissues. Their results reveal that grade 2 oligodendroglioma differs from other gliomas with a higher proportion of perturbed Alu subfamilies and the minimally-affected overall A-to-I editing and circular RNA levels, providing further insight into gliomagenesis.